Casa Santo Stefano is a restaurant at 1607 N 22nd St in Ybor City, Tampa. The restaurant is open daily from 11:00 a.m. to 10:00 p.m., so you can plan a lunch, an early dinner or a later meal
The menu draws on Sicilian home cooking. The lunch and dinner menus feature maccheroni (pasta), steaks, seafood, scacciata, salads, soups, desserts and hundreds of Sicilian wines. The website explains that much of what is served, from the wines to the cheese, olive oil and salt, is imported from family businesses in Sicily.
What to Expect at Casa Santo Stefano
The building was once a 1925 Ybor City macaroni factory, and the restaurant pays tribute to the Sicilian food owner Richard Gonzmart ate with his best friend Vincent Palori. The pastas, sauces and seafood are inspired by those Sunday meals, which the restaurant describes as Tampa Sicilian.
The interior is a showplace of art and craftsmanship. Hand-painted, colorful backsplashes, tabletops and countertops were ordered from a family in Caltagirone, Sicily. Vintage photographs on the walls represent many of the founding Sicilian families in Tampa, shared by their descendants.
The antipasti menu includes Meatballs della Nana, Salsiccia alla Griglia, Arancini al Burro, Calamari Fritti and Mussels J. Matassini. Antipasti generally range to. The pizzas are 12-inch, thin-crust, Sicilian-style pies cooked in a brick oven, including a Margherita and a Sicilian Hot Honey pizza.
The website asks that baseball caps be removed and men wear sleeves in the dining room. Guests often visit for celebrations and special occasions, so some dress more formally.
Planning Your Visit: Hours and Contact
The restaurant is open daily from 11:00 a.m. to 10:00 p.m. Hours can change, so confirm before you go. You can call (813) 248-1925 with questions. The full address is 1607 N 22nd St, Tampa, FL 33605.
For parking, the website says you can park free across from the restaurant in the large Columbia lot between 21st and 22nd streets. Several other free lots are also nearby. The restaurant also offers curbside pickup, and you can book a reservation or order for pickup through the website at casasantostefano.com.
Tips Before You Go
I'd call the phone number before you go if you have a larger group or a special occasion in mind. Hours are the same each day, but checking ahead saves a wasted trip.
Santo's Drinkeria is the restaurant's rooftop indoor-outdoor space above the main dining room. It has a view of historic Ybor City, craft cocktails and Sicilian street food. The website lists its hours as 5 to 10 p.m. Monday through Thursday and 4 to 11 p.m. on Friday and Saturday, with live music on Fridays.
If you're visiting Ybor City, the restaurant is a short walk from other sights the website highlights, including the Ybor City Museum State Park and the Columbia Restaurant.






